2020 AAHA/AAFP Feline Vaccination Guidelines
https://catvets.com/guidelines/practice-guidelines/aafp-aaha-feline-vaccination
Prognostic factors in cats with feline panleukopenia
J Vet Intern Med Nov-Dec 2010;24(6):1271-6.
doi: 10.1111/j.1939-1676.2010.0604.x. Epub 2010 Oct 12. B D Kruse 1 , S Unterer, K Horlacher, C Sauter-Louis, K Hartmann
Summary: Vaccination strategies that don’t include vaccination of kittens beyond 12 weeks of age may not be adequate: 51% survival rate overall, regardless of whether vaccinated, but NO cats had vaccines past 12 weeks of age.
Duration of immunity for canine and feline vaccines: A review 2006 Elsevier
Ronald D.Schultz Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA
Summary: Last dose of core vaccines after 12 weeks of age, revaccination at 1 year, then not more often than every 3 years should provide a level of protection to that achieved by annual revaccination (core vaccines ONLY).
Noncore, such as feline leukopenia vaccines, are needed at least once a year
Vaccine use and disease prevalence in dogs and cats
Vet Microbiol 2006 Oct 5;117(1):2-8.
doi: 10.1016/j.vetmic.2006.04.002. Epub 2006 Apr 18.
Summary: Base immunization is complete only after the booster in the 2nd year of life
Duration of serologic response to three viral antigens in cats
J Am Vet Med Assoc 2004 Jan 1;224(1):61-6.
doi: 10.2460/javma.2004.224.61.
Douglas E Mouzin 1 , Marianne J Lorenzen, John D Haworth, Vickie L King
Summary: Study of 276 client owned cats. Challenged with virulent virus between 9 and 36 months after vaccination. For laboratory-reared cats, the results were 90-100% positive. For client owned cats, 70.7% positive for FHV-1, 92.4% against FCV, and 68.5% against FPV.
Feline panleuk, feline — and feline calicivirus antibody responses to seronegative specific pathogen-free cats after a single administration of 2 different modified live FVRCP vaccines
J Feline Med Surg 2009 Feb;11(2):159-62. doi: 10.1016/j.jfms.2008.05.004. Epub 2008 Sep 7.
Summary: The 2006 AAFP feline vaccine Advisory Panel recommends vaccines until 16 weeks of age for FPV –in shelters, modified live is better.
In most infections in cats, the presence of serum antibodies indicates the cat has the immunologic memory required for a rapid immune response.
Studies indicate all cats with antibodies against FPV as a result of vaccination in the preceding 7 years were protected against the USDA challenge strain and dose of FPV.
Vaccination for FCV and FHV-1 doesn’t prevent infection, it lessens clinical disease. But cats vaccinated 30-36 months earlier, was predictive of disease resistance following challenges. In that study, of all cats with detectable antibodies, 90% had greater than 50% reduction in magnitude of clinical signs compared to unvaccinated control cats.
Maximum booster interval is 4 weeks. Kittens presented for booster 6 weeks or longer after the previous dose need 2 more doses at a minimum.